Premium
Estrogen induced hypertriglyceridemia in an apolipoprotein AV deficient patient
Author(s) -
Henneman P.,
Schaap F. G.,
Rensen P. C. N.,
Dijk K. W. van,
Smelt A. H. M.
Publication year - 2008
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.2007.01889.x
Subject(s) - endocrinology , medicine , hypertriglyceridemia , lipoprotein lipase , very low density lipoprotein , apolipoprotein b , triglyceride , chylomicron , lipolysis , lipoprotein , adipose tissue , cholesterol
Dear Sir, Occasionally severe hypertriglyceridemia (HTG) might develop or exacerbate in females during pregnancy or by use of exogenous oestrogens [1–3]. Oestrogens might increase production of triglyceride-rich very low density lipoproteins (VLDL) by the liver and impair lipolysis of triglycerides through reduction of the concentration of lipoprotein lipase, and hepatic lipase [4, 5]. These effects might be induced as a result of a decrease of insulin sensitivity by oestrogens [6, 7].