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Polycystic kidney disease: genes, proteins, animal models, disease mechanisms and therapeutic opportunities
Author(s) -
Torres V. E.,
Harris P. C.
Publication year - 2007
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.2006.01743.x
Subject(s) - polycystic kidney disease , medicine , disease , clinical trial , kidney disease , bioinformatics , intensive care medicine , animal model , pathology , biology
. An increased understanding of the genetic, molecular and cellular mechanisms responsible for the development of polycystic kidney disease has laid out the foundation for the development of rational therapies. Many animal models where these therapies can be tested are currently available. This review summarizes the rationale for these treatments, the results of preclinical trials and the prospects for clinical trials, some already in early phases of implementation.