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Intravenous polyclonal IgM‐enriched immunoglobulin therapy in sepsis: a review of clinical efficacy in relation to microbiological aetiology and severity of sepsis
Author(s) -
NORRBYTEGLUND A.,
HAQUE K. N.,
HAMMARSTRÖM L.
Publication year - 2006
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.2006.01726.x
Subject(s) - medicine , sepsis , immunology , clinical trial , polyclonal antibodies , septic shock , antibody , etiology , intensive care medicine
. The efficacy of intravenous polyclonal immunoglobulin (IVIG) as adjunct therapy in sepsis has long been debated. Clinical trials have yielded contradicting results, in part due to the varying study design and varying microbiological aetiologies. In most trials, the study drug has been IVIG containing polyclonal IgG. However, in recent reports, the efficacy of IgM‐enriched IVIG as adjunct therapy in sepsis has been highlighted. Here we review studies on IgM‐enriched IVIG therapy in sepsis and we discuss the clinical efficacy in relation to microbiological aetiology and severity of sepsis. The results suggest that patients most likely to benefit from IgM‐enriched IVIG therapy are those with Gram‐negative septic shock.