Premium
Amphoterin as an extracellular regulator of cell motility: from discovery to disease
Author(s) -
Huttunen H. J.,
Rauvala H.
Publication year - 2004
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.2003.01301.x
Subject(s) - autocrine signalling , regulator , motility , extracellular , paracrine signalling , microbiology and biotechnology , cell , cell migration , biology , genetics , cell culture , gene , receptor
. Amphoterin is a ubiquitous and highly conserved protein previously considered solely as a chromatin‐associated, nuclear molecule. Amphoterin is released into the extracellular space by various cell types, and plays an important role in the regulation of cell migration, differentiation, tumorigenesis and inflammation. This paper reviews recent research on the mechanistic background underlying the biology of secreted amphoterin, with an emphasis on the role of amphoterin as an autocrine/paracrine regulator of cell migration.