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Life events and neurocirculatory asthenia. A controlled study
Author(s) -
Sonino N.,
Fava G. A.,
Fava G. A.,
Boscaro M.,
Fallo F.
Publication year - 1998
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1998.00399.x
Subject(s) - medicine , outpatient clinic , pediatrics
Sonino N, Fava GA, Boscaro M, Fallo F (University of Padova, Padova, University of Bologna, Bologna, Italy; and State University of New York at Buffalo, NY USA). Life events and neurocirculatory asthenia. A controlled study. J Intern Med 1998; 244 : 523–8. Objectives : The purpose of this study was to assess the occurrence of stressful life events in the year before the onset of neurocirculatory asthenia. Design : Case‐control retrospective study. Setting : A university medical outpatient clinic. Subjects : A consecutive series of 50 patients with neurocirculatory asthenia and a control group of 50 healthy subjects, matched for sociodemographic variables, were studied. Main outcome measures : Paykel's Interview for Recent Life Events (a semistructured research interview covering 64 life events) was administered to patients and controls. Results : Patients with neurocirculatory asthenia reported significantly more stressful life events than the control group ( P < 0.05) and had significantly more of the following: exits ( P < 0.05), undesirable ( P < 0.05) and uncontrolled ( P < 0.01) events. More events that had an objective negative impact ( P < 0.001) and more independent events ( P = 0.07) were also reported. Ratings of impact and independence were carried out by a blind rater who was unaware whether the event had occurred in patients or controls. Conclusions : The results are suggestive of a strong relationship between stressful life events and neurocirculatory asthenia. This is in agreement with a multifactorial model of pathogenesis in neurocirculatory asthenia and with current understanding of the extensive links of behavioral responses to stress with neurophysiological and biochemical processes.