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Bone mass and riks factors for bone los in perimenopausal Danish women
Author(s) -
BROT C.,
JENSEN L. B.,
SØRENSEN O. H.
Publication year - 1997
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1997.tb00024.x
Subject(s) - medicine , anthropometry , body mass index , menopause , risk factor , bone mineral , amenorrhea , weight loss , bone density , longitudinal study , prospective cohort study , osteoporosis , gynecology , obstetrics , obesity , pregnancy , pathology , biology , genetics
. Brot C, Jensen LB, Smensen OH (Copenhagen Municipal Hospital, Copenhagen, Denmark). Bone mass and risk factors for bone loss in perimenopausal Danish women Objectives: To determine risk factors for low bone mass at menopause and risk factors for subsequent bone loss in the following period. Design: A cross‐sectional study and a 2‐year prospective follow‐up. Setting: The catchment area of Sundby Hospital in Copenhagen. Subjects: Four hundred and thirty‐three women aged 45–58 years, with amenorrhea for 3–24 months, of whom 87 were followed for a 2‐year period. Measurements: Registration of life‐style and anthropometric variables, reproductive history, and family history of fractures. Total body bone mineral content (BMC) was measured with dual energy X‐ray absorptiometry. Results: By means of multiple regression analysis height, body weight, and length of reproductive period were found to be positively related to whole body BMC (P < 0.001), whilst a negative relationship was found to age (P < 0.001), smoking (P < 0.001), and family history of fractures (P < 0.005). In the longitudinal study, only body weight at the inclusion (P = 0.005) and subsequent changes in body weight and fat mass (P < 0.001) were related to the changes in bone mass. Conclusion: The most significant predictors for bone loss were changes in body weight and fat mass. Hence, weight loss is a risk factor for bone loss in the early postmenopausal period, whereas weight gain seems to preserve bone.