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Obesity worsens cardiovascular risk profiles independently of hyperinsulinaemia
Author(s) -
BONORA E.,
TARGHER G.,
ZENERE M. B.,
SAGGIANI F.,
ALBERICHE M. P.,
BRANZI P.,
MUGGEO M.
Publication year - 1997
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1997.tb00003.x
Subject(s) - medicine , endocrinology , blood pressure , hyperinsulinemia , body mass index , insulin , triglyceride , obesity , diabetes mellitus , high density lipoprotein , cholesterol , insulin resistance
. Bonora E, Targher G, Zenere MB, Saggiani F, Alberiche MP, Branzi P, Muggeo M. (University of Verona Medical School, Verona, Italy). Obesity worsens cardiovascular risk profiles independently of hyperinsulinaemia. Objective: To investigate whether human obesity is characterized by a worse cardiovascular risk profile (than no obesity) even in the absence of hyperinsulinaemia. Subjects and design: A total of 367 healthy subjects (247 nonobese and 120 obese) with normal glucose tolerance and without family history of diabetes mellitus. Interventions: A 75‐g oral glucose tolerance test was performed in all participants. Main outcome measures: Anthropometry, blood pressure, fasting plasma lipids and urate, plasma glucose and insulin concentrations at fasting, 1 h and 2 h after oral glucose load. Results: In a multivariate linear regression analysis, body mass index was strongly related to all cardiovascular risk factors, independently of sex, age and plasma insulin. When risk factors were compared in 37 normoinsulinaemic obese subjects (plasma insulin within one standard deviation of the mean values observed in the 247 nonobese subjects), and in 37 sex‐ and age‐matched normoinsulinaemic nonobese subjects, we found that plasma glucose levels were similar in the two groups, whereas plasma triglyceride (1.50pL0.13 vs. 1.13pL0.08 mmol L ‐1 ; mean pL SE). low‐density lipoprotein cholesterol (3.42pL0.25 vs. 2.77pL0.18 mmol L ‐1 ) and urate (290pL12 vs. 255pL12 umol L ‐1 ) levels were significantly higher, and plasma high‐density lipoprotein cholesterol concentrations were lower (1.27pL0.04 vs. 1.46pL0.06 mmol L ‐1 ) in obese than in nonobese subjects with normal plasma insulin levels (P<0.01). Also systolic (132pL2 vs. 124pL2 mmHg) and diastolic (86pL1 vs. 81pL1 mmHg) blood pressure values were significantly higher in normoinsulinaemic obese subjects than in normoinsulinaemic nonobese individuals (P<0.001). Conclusions: These results suggest that in human obesity a worse cardiovascular risk profile is found (than in the nonobese) independently of the presence of hyperinsulinaemia.