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Dramatic responses to intravenous immunoglobulin in vasculitis *
Author(s) -
BOMAN S.,
BALLEN J. L.,
S. Seggev Joram
Publication year - 1995
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1995.tb01213.x
Subject(s) - medicine , vasculitis , intravenous immunoglobulins , antibody , immunology , immunoglobulin a , immunoglobulin g , disease
. Intravenous immunoglobulin (IVIG) has been successfully used to treat autoimmune diseases. We report dramatic, rapid and sustained responses to its use in two cases of vasculitis: a patient with primary angiitis of the central nervous system; and a patient with hepatitis‐B‐antigen‐related polyarteritis nodosa, who failed treatment with corticosteroids. Improvement in gait and a marked decrease in serum creatinine, respectively, were observed within 24 h of the first dose of IVIG. Both patients remained stable for several months. We conclude that IVIG should be considered in patients with vasculitis who fail corticosteroids, or when a rapid response is required.