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Frequency of diabetes in family members of probands with non‐insulin‐dependent diabetes mellitus
Author(s) -
SIMMONS D.,
GATLAND B. A.,
LEAKEHE L.,
FLEMING C.
Publication year - 1995
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1995.tb01181.x
Subject(s) - diabetes mellitus , medicine , family history , pregnancy , proband , offspring , demography , ethnic group , insulin , obstetrics , endocrinology , biochemistry , chemistry , genetics , sociology , gene , anthropology , mutation , biology
. Objectives . To describe the prevalence of known diabetes in a multi‐ethnic community in South Auckland, New Zealand, in relation to family history of diabetes and past history of diabetes in pregnancy. Design . A cross‐sectional, household survey comparing ascertainment with local general practice diabetes registers where they existed. Setting . An inner‐city community with a high proportion of Maori, Pacific Islands people and Europeans. Subjects . A total of 55518 residents (91% response). Comparison with diabetes registers showed 91% ascertainment of known diabetic residents. More detailed interviews with 176/214 (82%) Europeans, 286/336 (85%) Maori and 495/585 (85%) Pacific Islands people with known diabetes. Fifty subjects had insulin‐dependent diabetes mellitus on clinical criteria and were excluded from analyses. Main outcome measures . Prevalence of diabetes. Results . Those with non‐insulin‐dependent diabetes mellitus were more likely to have a diabetic mother than father (Europeans, 21.7% vs. 9.9%; Maori, 17.6 vs. 11.4%; Pacific Islands, 15.7 vs. 5.3%). Diabetic women had a similar likelihood of having a diabetic father as diabetic men but were 1.84 times as likely to have a diabetic mother (95% CI, 1.27–2.69). Diabetic women with past diabetes in pregnancy had 2.05 (95% CI, 1.01–4.15) times the chance of a diabetic offspring as women who had not had past diabetes in pregnancy, who in turn had 2.69 (95% CI, 1.17–6.18) times the likelihood of having a diabetic offspring as diabetic men. Conclusions . The mother is a more important conduit for inheritance of diabetes than the father in these three ethnic groups. A history of diabetes in pregnancy confers an extra risk to the offspring above this usual maternal excess.