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Genetic mapping of the multiple endocrine neoplasia type 1 locus at 11q13
Author(s) -
TEH B. T.,
CARDINAL J.,
SHEPHERD J.,
HAYWARD N. K.,
WEBER G.,
CAMERON D.,
LARSSON C.
Publication year - 1995
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1995.tb00931.x
Subject(s) - men1 , multiple endocrine neoplasia , locus (genetics) , genetics , gene mapping , biology , gene , carcinogenesis , chromosomal region , genetic linkage , deletion mapping , loss of heterozygosity , microsatellite , chromosome , allele
. Oncogenesis of tumours related to multiple endocrine neoplasia type 1 (MEN1) is associated with somatic deletions involving the MEN1 locus at chromosomal region 11q13, suggesting inactivation of a tumour‐suppressor gene in this region. Here we describe the localization of the MEN1 gene to a 900‐kb region, based on linkage analysis in affected families and deletion mapping of MEN1‐associated tumours. In addition, a set of microsatellite markers mapped to the 11q11–13 region were used for linkage analysis in a large Tasmanian MEN1 pedigree, demonstrating the usefulness of these markers for presymptomatic testing in affected families.