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Candidate genes for multiple endocrine neoplasia type 1
Author(s) -
LAGERCRANTZ J.,
LARSSON C.,
GRIMMOND S.,
SKOGSEID B.,
GOBL A.,
FRIEDMAN E.,
CARSON E.,
PHELAN C.,
ÖBERG K.,
NORDENSKJÖLD M.,
HAYWARD N. K.,
WEBER G.
Publication year - 1995
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1995.tb00930.x
Subject(s) - medicine , multiple endocrine neoplasia , multiple endocrine neoplasia type 2 , gene , endocrine system , type (biology) , genetics , hormone , biology , mutation , germline mutation , ecology
. The aim of this study was to isolate and characterize candidates for the multiple endocrine neoplasia type 1 (MEN1) gene. The development of tumours related to MEN1 is associated with somatic deletions involving the MEN1 locus, suggesting inactivation of a tumour‐suppressor gene in this region. We have isolated five cDNA candidates located within the 900 kb remaining for the MEN1 gene, determined their sequence, and characterized their expression in normal tissues and several endocrine tumours. One of the candidates, encoding for phospholipase C‐β3, showed properties consistent with the idea of a tumour‐suppressor gene.