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Effects on glucose tolerance, insulin secretion, insulin‐like growth factor 1 and its binding protein, IGFBP‐1, in a randomized controlled diet and exercise study in healthy, middle‐aged men
Author(s) -
HELLÉNIUS MAILIS B.,
BRISMAR KERSTIN E.,
BERGLUND BO H.,
FAIRE ULF H.
Publication year - 1995
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1995.tb00909.x
Subject(s) - medicine , insulin , endocrinology , insulin like growth factor binding protein , insulin like growth factor , randomized controlled trial , growth factor , receptor
. Objectives . To study the effects of advice on diet, exercise and their combination on oral glucose tolerance (OGTT), insulin secretion, insulin‐like growth factor‐1 (IGF‐1) and its binding protein, IGFBP‐1. Design . A 6‐month, randomized, controlled intervention study. Setting . Primary health care centres in Sollentuna, Stockholm and the Department of Medicine, Karolinska Hospital, Stockholm, Sweden. Subjects . One hundred and fifty‐seven normoglycaemic healthy men, mean age 46 years, range 35–60 years, with slightly to moderately raised cardiovascular risk factors. Interventions . Advice on diet (D, n = 40), exercise (E, n = 39) a combination of both (DE, n = 39) and a control group (C. n = 39). Main outcome measures . An OGTT, insulin secretion, IGF‐1 and its binding protein, IGFBP‐1. Results . The number of pathological OGTTs in the intervention groups decreased from 42/118 to 33/118 whilst the number in the control group did not change. Fasting insulin levels decreased in groups E and DE from 8.8–7.4 mU L −1 ( P < 0.01) and from 8.3–6.7 mU L −1 ( P < 0.01), respectively. Accordingly, the insulin area under the curve decreased from 5278 to 4828 ( P < 0.05) in group E, and from 5482 to 4809 ( P < 0.01) in group DE. IGF‐1 only increased in group D. The most prominent changes were noted for IGFBP‐1, which increased in all three intervention groups and to the highest degree in group DE (from 33.7–42.6 μg L −1 , P < 0.001). Conclusions . A combination of increased exercise and improved diet, as well as increased exercise alone, favourably affect glucose and insulin homeostasis in middle‐aged men with moderately elevated cardiovascular risk factors. The most marked changes were noted for IGFBP‐1, possibly suggesting a decreased insulin secretion and an enhanced insulin sensitivity.