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Apoptosis: molecular mechanisms and implications for human disease
Author(s) -
ORRENIUS STEN
Publication year - 1995
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1995.tb00881.x
Subject(s) - apoptosis , programmed cell death , intracellular , necrosis , disease , microbiology and biotechnology , mechanism (biology) , cell , medicine , atrophy , cell type , biology , neuroscience , immunology , pathology , genetics , philosophy , epistemology
. Apoptosis is a highly regulated process of cell death with characteristic morphological changes that are distinct from necrosis. The biochemical machinery responsible for apoptotic cell death appears to be constitutively expressed in most, if not all, cells and can be triggered by a variety of signals, including sustained increases in the intracellular Ca 2+ level. Apoptosis is the main mechanism of cell deletion during development, normal cell turnover, hormone‐induced tissue atrophy, and pathological processes such as T‐cell depletion in HIV/AIDS and neurodegenerative disease. The aim of this review is to briefly summarize current knowledge of the molecular mechanisms of apoptosis and its role in human disease.