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Paraneoplastic vasculitic neuropathy: immunohistochemical studies on a biopsied nerve and post‐mortem examination
Author(s) -
MATSUMURO K.,
IZUMO S.,
UMEHARA F.,
ARISATO T.,
MARUYAMA I.,
YONEZAWA S.,
SHIRAHAMA H.,
SATO E.,
OSAME M.
Publication year - 1994
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1994.tb01287.x
Subject(s) - medicine , immunohistochemistry , pathology , vasculitis , sural nerve , peripheral neuropathy , cd8 , immune system , immunology , disease , diabetes mellitus , endocrinology
. We studied a patient with paraneoplastic vasculitic neuropathy (PVN) associated with a carcinoma of the common bile duct. Immunohistochemical analysis of the biopsied sural nerve showed that the cellular infiltrates in the vascular lesions were composed primarily of CD8‐positive T lymphocytes and macrophages. Pathogenic significance of the T‐cell‐mediated immunological reaction was suggested. Post‐mortem examination revealed the absence of systemic vasculitis, which may be a characteristic feature of PVN. The patient responded to immunosuppressive treatment. We discuss the efficacy and the risk of immunosuppressive therapy for PVN.