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Disturbances of T‐cell interactions with endothelium and the extracellular matrix proteins in a patient with Takayasu arteritis
Author(s) -
IMIElA J.,
GÓRSKI A.,
DYBOWSKA B.,
MALECKI R.,
NOSARZEWSKI J.
Publication year - 1994
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1994.tb01269.x
Subject(s) - fibronectin , extracellular matrix , medicine , endothelium , pathogenesis , extracellular , immunology , in vitro , microbiology and biotechnology , pathology , biology , endocrinology , biochemistry
. T‐cell interactions with endothelium and the extracellular matrix proteins were studied in vitro in a patient with Takayasu arterisis. Markedly enhanced spontaneous adhesiveness to cultured endothelium and collagen IV and fibronectin were found to be paralleled by abolished responses to the costimulating action of collagens I and IV and fibronectin. Those abnormalities were partly corrected by immunosuppressive therapy. Aberrant interactions of T cells with endothelium and the extracellular matrix proteins may underlay the pathogenesis of some forms of vasculitis.