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A catastrophic antiphospholipid syndrome: the importance of high levels of warfarin anticoagulation
Author(s) -
Ruffatti A.,
Silvestro G.,
Ghirardello A.,
Calligaro A.,
Ross T.,
Thiene G.,
Todesco S.
Publication year - 1994
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1994.tb01036.x
Subject(s) - medicine , catastrophic antiphospholipid syndrome , warfarin , lupus anticoagulant , antiphospholipid syndrome , anticoagulant , antibody , anticardiolipin antibodies , thrombosis , immunology , atrial fibrillation
. We report the clinical observation of a 23‐year‐old woman affected by the so‐called ‘catastrophic antiphospholipid syndrome’. Within a 3‐month period she suffered a number of thrombotic events and haemolytic anaemia with thrombocytopenia and had high levels of immunoglobulins G and M and anticardiolipin antibodies associated with lupus anticoagulant activity. The severity of the clinical and laboratory changes is described and diagnostic and therapeutic difficulties are discussed. The apparent control of thrombotic events only with high levels of warfarin anticoagulation is stressed.