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Acute cholestatic hepatitis and the sudden rise of the pacing threshold 5 weeks after VVI‐pacemaker implantation
Author(s) -
SCHÜPPEL R.,
PROBST M.
Publication year - 1994
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1994.tb00808.x
Subject(s) - medicine , complication , propafenone , cholestatic hepatitis , myocardial infarction , cardiology , hepatitis , anesthesia , atrial fibrillation
. The patient we describe developed a cholestatic hepatitis and an unusual threshold elevation of about 425%, coincidently, 5 weeks after pacemaker implantation. Lead dislocation, myocardial infarction or metabolic disorder could be excluded as a reason for the pacemaker complication. Neither a biliary obstruction nor an infection of the liver could be found to explain the liver injury. Most probably, both disorders were caused by propafenone (450 mg day −1 ), withdrawal of the drug resulted in normalization of elevated enzyme and threshold levels.