Premium
Sucralfate suspension as a treatment of recurrent aphthous stomatitis
Author(s) -
RATTAN J.,
SCHNEIDER M.,
ARBER N.,
GORSKY M.,
DAYAN D.
Publication year - 1994
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1994.tb00805.x
Subject(s) - sucralfate , medicine , recurrent aphthous stomatitis , antacid , placebo , stomatitis , double blind , surgery , gastroenterology , alternative medicine , pathology
. Design. A prospective randomized, double‐blind, placebo‐controlled, cross‐over clinical trial. Setting. A university hospital. Subjects. Twenty‐one patients with symptomatic recurrent aphtous stomatitis (RAS), unresponsive to conventional treatment were enrolled. They were divided into three groups. Intervention. In a cross‐over trial, the patients received an oral suspension of sucralfate, an antacid solution or a placebo for 2 years. Results. After 2 years of follow‐up, sucralfate was found to be superior to both placebo and antacid ( P < 0.001) with regard to duration of pain, reduction of the healing period, response time to first treatment and duration of remission. Conclusion. Sucralfate suspension should be added to the armament of treatment modalities of RAS.