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Liver reactions from trimethoprim
Author(s) -
LINDGREN A.,
OLSSON R.
Publication year - 1994
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1994.tb00797.x
Subject(s) - trimethoprim , medicine , drug reaction , incidence (geometry) , adverse drug reaction , adverse effect , gastroenterology , drug , pharmacology , antibiotics , biochemistry , chemistry , physics , optics
. Objective. To study whether there are adverse liver reactions to trimethoprim and, if found, to describe the biochemical pattern of these reactions. Design. We surveyed all liver reactions from trimethoprim to SADRAC (Swedish Adverse Drug Reactions Advisory Committee) from 1980 to 1989. Main outcome measure. Incidence of reported adverse liver reactions [number of reported adverse liver reactions/sales of trimethoprim in defined daily dose (DDD)]. Results. During 1980–1989, 21 suspected liver reactions from trimethoprim were reported. A causal relationship was considered probable in 10 of these reports, which gives an incidence of 1/1360000 DDD. The distribution of reaction types for trimethoprim was virtually identical to that found in corresponding adverse reports for trimethoprim‐sulfonamides, whereas the sulfonamides as single drugs displayed a significantly higher proportion of more severe hepatocellular reactions.