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Autoimmune polyglandular failure associated with malabsorption and gastric carcinoid tumour
Author(s) -
LEIBOWITZ G.,
AMIR G.,
LOSSES I. S.,
ELIAKIM R.
Publication year - 1993
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1993.tb01025.x
Subject(s) - medicine , malabsorption , steatorrhea , gastroenterology , asymptomatic , endocrinology , pernicious anaemia , diabetes mellitus , exocrine pancreatic insufficiency , carcinoid tumour , pancreatitis
. A 21‐year‐old female with autoimmune polyglandular failure (APG) manifested by insulin‐dependent diabetes mellitus (IDDM), hypothyroidism and pernicious anaemia developed severe malabsorption due to exocrine pancreatic insufficiency. Supplemental pancreatic enzymes resulted in marked improvement of steatorrhea. There was also an incidental finding of gastric carcinoid tumour. We identified only 13 other patients in our institution with either type 2 or 3 APG, one of which had significant steatorrhoea. Another patient with IDDM, hypothyroidism and pernicious anaemia had an asymptomatic gastric carcinoid tumour. The possible mechanisms for malabsorption in APG are discussed.