Premium
Thiazide‐induced kidney damage with circulating antibodies against myeloperoxidase and cardiolipin
Author(s) -
LARSSON G. B.,
LANGER L.,
NÄSSBERGER L.
Publication year - 1993
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1993.tb01004.x
Subject(s) - medicine , antibody , myeloperoxidase , cardiolipin , kidney , thiazide , anti nuclear antibody , immunology , gastroenterology , autoantibody , diuretic , inflammation , biochemistry , phospholipid , membrane , chemistry
. A 79‐year‐old man developed a renal insufficiency while on thiazide. Extrarenal symptoms were absent. Screening for antibodies revealed high titre for anti‐myeloperoxidase and anti‐cardiolipin antibodies, but no other antibodies were present. After withdrawal of the drug the progression of renal insufficiency ceased. Four months later the both antibodies had disappeared. We conclude, that antibodies against granulocytes will become a valuable diagnostic tool in diagnosing drug‐induced vasculitis.