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Severe skin necrosis following warfarin therapy in a patient with protein C deficiency
Author(s) -
LOCHT H.,
LINDSTRÖM F. D.
Publication year - 1993
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1993.tb00989.x
Subject(s) - warfarin , medicine , protein s deficiency , heparin , necrosis , thrombosis , protein c deficiency , venous thrombosis , anticoagulant , surgery , protein c , atrial fibrillation
. A female patient with a history of both arterial and venous thrombosis developed extensive skin necrosis following warfarin treatment. When protein C deficiency was diagnosed, successful anticoagulation with warfarin was achieved by prolonging the course of intravenous heparin and introducing warfarin therapy with a low initial dose which was gradually increased. Aspects of the pathogenic mechanism are discussed.