Premium
HLA‐DR3, DQ2 homozygosity in two patients with insulin‐dependent diabetes mellitus superimposed with ulcerative colitis and primary sclerosing cholangitis
Author(s) -
IVARSSON S.A.,
ERIKSSON S.,
KOCKUM I.,
LERNMARK Å.,
LINDGREN S.,
NILSSON K. O.,
SUNDKVIST G.,
WASSMUTH R.
Publication year - 1993
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1993.tb00988.x
Subject(s) - medicine , ulcerative colitis , primary sclerosing cholangitis , diabetes mellitus , human leukocyte antigen , autoimmune disease , gastroenterology , genotype , disease , immunopathology , immunology , endocrinology , genetics , gene , biology , antigen
. Two unrelated young males with the unusual simultaneous presence of insulin‐dependent diabetes mellitus, ulcerative colitis and primary sclerosing cholangitis are reported. Both patients manifested homozygosity for the DR3‐DQw2 (DQB*0201) HLA genotypes. We believe that homozygosity for this genotype may predispose for this type of multi‐organ autoimmune disease.