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Polyautoimmune syndrome in common variable immunodeficiency
Author(s) -
TANUS T.,
LEVINSON A. I.,
ATKINS P. C.,
ZWEIMAN B.
Publication year - 1993
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1993.tb00788.x
Subject(s) - medicine , common variable immunodeficiency , vitiligo , immunology , rheumatoid arthritis , pernicious anemia , immunodeficiency , atrophic gastritis , primary immunodeficiency , thyroiditis , thrombocytopenic purpura , primary biliary cirrhosis , parotitis , immune system , antibody , gastritis , disease , anemia , gastroenterology , stomach , dentistry
. Common variable immunodeficiency (CVI) is a heterogenous disorder with hypogammaglobulinaemia and multiple bacterial infections primarily involving the sinopulmonary tract. CVI patients have been known to have an increased tendency to develop autoimmune manifestations. Commonly associated autoimmune diseases include immune thrombocytopenic purpura, autoimmune haemolytic anaemia, and rheumatoid arthritis. In this paper we report a case of CVI presenting with multiple unusual autoimmune diseases including parotitis, vitiligo, atrophic gastritis, pernicious anaemia, and primary biliary cirrhosis. To our knowledge, this is the first case of CVI with polyautoimmunity and anti‐mitochondrial antibody. Recognition of this association is important because early diagnosis and treatment can greatly influence the prognosis.