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Essential cryofibrinogenaemia, leukocytoclastic vasculitis and chronic purpura
Author(s) -
JANTUNEN E.,
SOPPI E.,
NEITTAANMÄKI H.,
LAHTINEN R.
Publication year - 1993
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1993.tb00752.x
Subject(s) - medicine , leukocytoclastic vasculitis , purpura (gastropod) , palpable purpura , dermatology , vasculitis , malignancy , immunology , pathology , henoch schonlein purpura , disease , ecology , biology
. Cryofibrinogenaemia refers to the presence of cold‐precipitable proteins in plasma but not in serum. It is usually associated with malignancy, tromboembolic diseases or various inflammatory processes; rarely it may be essential. The most common clinical presentations of cryofibrinogenaemia are cold‐intolerance, purpura, skin necrosis and ulcers. We describe a middle‐aged woman with essential cryofibrinogenaemia, leukocytoclastic vasculitis, and chronic purpura for over 25 years with several exacerbations. In patients with otherwise unexplained purpura or skin necrosis, determination of plasma cryofibrinogen should be considered.