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Thrombocytopenia following administration of phenytoin, dexamethasone and cimetidine: a case report and a potential mechanism
Author(s) -
ARBISER J. L.,
GOLDSTEIN A. M.,
GORDON D.
Publication year - 1993
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1993.tb00710.x
Subject(s) - cimetidine , phenytoin , medicine , dexamethasone , pharmacology , drug interaction , mechanism (biology) , epilepsy , drug , psychiatry , epistemology , philosophy
. Cimetidine and phenytoin are useful medications often used together in patients with seizure disorders secondary to brain masses or metabolic abnormalities. We describe a case of thrombocytopenia in the setting of concurrent phenytoin, dexamethasone and cimetidine administration, and compare it with previously described cases of thrombocytopenia induced by concurrent use of phenytoin, cimetidine, and glucocorticoids. The similarities between these cases suggest mechanisms by which these agents may induce thrombocytopenia, specifically through potential downregulation of epoxide hydrolase by glucocorticoids.