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Renal failure due to sulphadiazine in AIDS patients with cerebral toxoplasmosis
Author(s) -
FARIÑAS M. C.,
ECHEVARRÍA S.,
SAMPEDRO I.,
GONZALEZ A.,
MOLINO A. PÉREZ,
GONZÁLEZMACÍAS J.
Publication year - 1993
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1993.tb00685.x
Subject(s) - medicine , crystalluria , toxoplasmosis , pyrimethamine , complication , sulfadiazine , urine , surgery , anesthesia , immunology , antibiotics , malaria , chloroquine , calcium oxalate , microbiology and biotechnology , biology
. Cerebral toxoplasmosis is optimally treated with the combination of high doses of sulphadiazine and pyrimethamine. We described two patients with AIDS treated for cerebral toxoplasmosis who developed renal failure due to sulphadiazine‐induced crystalluria. Symptoms and renal failure were rapidly reversed with urine alkalinization and hydration. A careful monitoring and adequate hydration of patients with AIDS treated with high doses of sulphadiazine appears mandatory to avoid this complication.