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The acute‐phase response and associated lipoprotein abnormalities accompanying lymphoma
Author(s) -
BLACKMAN J. D.,
CABANA V. G.,
MAZZONE T.
Publication year - 1993
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1993.tb00674.x
Subject(s) - medicine , acute phase protein , serum amyloid a , lipoprotein , lymphoma , apolipoprotein b , endocrinology , cholesterol , triglyceride , chemotherapy , immunology , inflammation
. Lipoprotein abnormalities seen in patients with inflammatory diseases are thought to develop secondary to circulating cytokines and the accompanying acute‐phase response. Patient's with lymphoma may develop similar lipoprotein abnormalities but the mechanism is unclear. We report a patient with B‐cell lymphoma who presented with an HDL cholesterol level of 3 mg dl −1 , an ApoA level of 17.4 mg dl −1 , elevated triglyceride level (272 mg dl −1 ) and an elevated ApoB level of 156 mg dl −1 . Density gradient analysis of the patient's lipoproteins demonstrated a virtual absence of an identifiable HDL particle. Serum amyloid A and C‐reactive protein were also elevated. All of the lipoprotein abnormalities resolved with chemotherapy and resolution of the acute‐phase response. The acute‐phase response may be associated with striking lipoprotein abnormalities in a subset of patients with lymphoma. Lymphoma should be included in the differential diagnosis of patients with hypertriglyceridaemia and low HDL cholesterol.