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The predictive value of CKMB mass concentration in unstable angina pectoris: preliminary report
Author(s) -
MARKENVARD J.,
DELLBORG M.,
JAGENBURG R.,
SWEDBERG K.
Publication year - 1992
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1992.tb00956.x
Subject(s) - medicine , predictive value , unstable angina , cardiology , angina , value (mathematics) , coronary heart disease , myocardial infarction , statistics , mathematics
. Unstable angina pectoris is a common clinical problem, and the diagnosis is based on clinical symptoms. However, these symptoms cannot identify high‐risk patients. Holter monitoring can identify patients at high risk, but analysis of a large number of patients is time‐ and resource‐consuming, as is angiographic examination. We determined whether creatine kinase MB isoenzyme mass concentration could predict the prognosis for patients with unstable angina pectoris. A total of 101 consecutive patients were studied, and blood samples were collected three times a day for 48 h after admission. Patients with unstable angina and elevated CKMB (but still within the normal range) had a significantly higher risk of developing acute myocardial infarction or requiring revascularization during 6 months of follow‐up than patients without elevated CKMB. We conclude that CKMB analysis is a valuable tool that may be of use in selecting high‐risk patients with unstable angina pectoris. This finding needs to be confirmed by more extensive studies.