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Hyperglycaemic symptoms before diagnosis of non‐insulin‐dependent (type 2) diabetes mellitus in relation to 5‐year outcome
Author(s) -
Niskanen L.,
SIITONEN O.,
KARJALAINEN J.,
UUSITUPA M.
Publication year - 1992
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1992.tb00950.x
Subject(s) - medicine , polyuria , asymptomatic , polydipsia , diabetes mellitus , insulin , type 2 diabetes mellitus , weight loss , endocrinology , obesity
. A group of newly diagnosed patients with non‐insulin‐dependent (type 2) diabetes mellitus ( n = 133) were divided into two groups according to the symptoms of diabetes mellitus at diagnosis; a group (26 men and 17 women) with hyperglycaemic symptoms (polydipsia, polyuria, weight loss and tiredness) and a group (44 men and 46 women) without such symptoms. At the time of diagnosis, symptomatic patients tended to be leaner ( P = NS), and they were more hyperglycaemic ( P < 0.001‐0.06) and had lower insulin responses to an oral glucose load ( P < 0.01‐0.05) than asymptomatic patients, but after 5 years no difference in these respects was found. No significant differences in the frequency of islet‐cell antibodies or cardiovascular diseases were found between the two diabetic groups. At the 5‐year examination, the initially symptomatic patients were receiving pharmacological treatment for hyperglycaemia more often than asymptomatic patients. No consistent differences in clinical characteristics and 5‐year outcome were observed between those diabetic patients who were diagnosed on the basis of hyperglycaemic symptoms and those who were diagnosed for other reasons. In conclusion, in middle‐aged patients with newly diagnosed diabetes mellitus classified as non‐insulin‐dependent, diabetic symptoms at diagnosis did not predict the 5‐year outcome of the patients in terms of metabolic control or cardiovascular events.