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Amylase‐producing IgD‐type multiple myeloma
Author(s) -
DELANNOY A.,
HAMELS J.,
MECUCCI C.,
FALLY P.,
WALLEF G.,
FOOZ C.,
CARLIER B.
Publication year - 1992
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1992.tb00615.x
Subject(s) - amylase , immunoglobulin d , multiple myeloma , medicine , bone marrow , clone (java method) , cancer research , pathology , enzyme , biology , antibody , immunology , genetics , b cell , gene , biochemistry
We describe the case of a 63‐year‐old woman with an IgD‐type multiple myeloma and hyperamylasaemia. The evolution of the amylase concentration, the immunohistochemical data and the intracellular amylase contents of the plasma cell were consistent with secretion of amylase by the malignant clone. Moreover, cytogenetic analysis of the bone marrow revealed two structural rearrangements involving chromosome 1 near the amylase locus. Multiple myeloma should be added to the amylase‐secreting tumours. This rare entity is not confined to Japan, where it was first recognized.