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Hypersensitivity reaction associated with acute hepatic dysfunction following a single intravenous dose of procainamide
Author(s) -
WORMAN H. J.,
IP J. H.,
WINTERS S. L.,
TEPPER D. C.,
GOMES A. J.
Publication year - 1992
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1992.tb00599.x
Subject(s) - procainamide , medicine , chills , hepatic dysfunction , hypersensitivity reaction , drug , leukopenia , quinidine , anesthesia , pharmacology , toxicity
Rare cases of hepatotoxicity have been attributed to the antiarrhythmic agent procainamide. We here describe the case of a patient who had a hypersensitivity reaction to procainamide with fever, chills, arthralgia, abdominal pain and acute elevations of serum aminotransferase activities and bilirubin concentration. The reaction occurred after the patient had received a large intravenous dose during cardiac electrophysiological testing. This case should alert physicians to potential hepatotoxic reactions to procainamide, particularly with the increasing popularity of cardiac electrophysiological testing, during which this drug is commonly used.