Premium
Pulse cyclophosphamide therapy in Wegener's granulomatosis: a pilot study
Author(s) -
DROSOS A. A.,
SAKKAS L. I.,
GOUSSIA A.,
SIAMOPOULOS K. C.,
MOUTSOPOULOS H. M.
Publication year - 1992
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1992.tb00584.x
Subject(s) - medicine , cyclophosphamide , wegener granulomatosis , granulomatosis with polyangiitis , dermatology , systemic disease , pathology , vasculitis , immunopathology , chemotherapy , disease
Five patients with Wegener's granulomatosis (WG) have been treated with 6‐ to 8‐monthly pulses of intravenous cyclophosphamide (CP) and glucocorticoids in an open pilot study. One patient achieved complete remission sustained during 30 months of follow‐up; one patient had features of active disease after 28 months of remission; two patients after an initial remission had an exacerbation of the disease and received continuous oral administration of CP, and one patient required continuous oral CP to control the symptoms. These results suggest that this regimen may not achieve a high degree of sustained remission in patients with WG.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom