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Decreased erythrocyte cholesterol/phospholipid ratio in untreated patients with essential hypertension
Author(s) -
RONQUIST G.,
FRITHZ G.,
GUNNARSSON K.,
ARVIDSON G.
Publication year - 1992
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1992.tb00579.x
Subject(s) - phospholipid , medicine , cholesterol , essential hypertension , endocrinology , membrane , biochemistry , chemistry , blood pressure
The erythrocyte cholesterol/phospholipid ratio was determined in eight patients with untreated essential hypertension and compared with that of eight age‐matched control subjects. The ratio was significantly lower in patients (Wilcoxon's paired rank test; P < 0.01), and a correlation existed between the ratio and serum cholesterol concentration in patients ( r = 0.63) but not in controls ( r = 0.02). A reduction in the cholesterol/phospholipid ratio may play a direct role in destabilizing the plasma membrane, which will in turn result in an increase in membrane permeability in essential hypertension.