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Dexfenfluramine in the treatment of severe obesity: a placebo‐controlled investigation of the effects on weight loss, cardiovascular risk factors, food intake and eating behaviour
Author(s) -
MATHUSVLIEGEN E. M. H.,
VOORDE K.,
KOK A. M. E.,
RES A. M. A.
Publication year - 1992
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1992.tb00560.x
Subject(s) - dexfenfluramine , medicine , obesity , weight loss , placebo , food intake , fenfluramine , alternative medicine , receptor , pathology , serotonin
Dexfenfluramine, an effective and safe serotoninergic drug with anorectic and possible food‐selection‐tuning properties, was investigated in a placebo‐controlled study of 1 year's duration in severe and refractory obesity. The aim of the study was to assess weight loss, and changes in cardiovascular risk factors, food intake and eating behaviour. Dexfenfluramine‐ and placebo‐treated patients achieved a similar weight loss (> 10% of initial weight, by 39.5 and 30.0%, > 20% of initial overweight by 42.1% and 32.5% and > 10 kg by 41.4 and 33.3%, respectively, of the initial cohorts). Furthermore, the decreases in weight (10.7 vs. 8.0 kg), in body mass index (3.9 vs. 2.9 kg m −2 ) and in waist/hip ratio (0.04 vs. 0.02) were not significantly different. After discontinuation of the drug, the increase in weight (2.8 vs. 1.0 kg) was significantly higher in the dexfenfluramine‐treated group. Except for a borderline better effect on glucose of dexfenfluramine, both groups showed similar beneficial changes in food intake and cardiovascular risk factors. Eating behaviour in response to emotional and external stimuli was comparable in the two groups, but placebo‐treated patients had to restrain their eating more in order to achieve the same weight loss. Notwithstanding the fact that weight losses and an associated amelioration of health‐risk factors were of similar magnitude in dexfenfluramine‐ and placebo‐treated patients, dexfenfluramine might have a useful role in promoting a less stressed adherence to prolonged restriction of energy intake in the severe and refractory obese subject.