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Calcium antagonism in essential hypertension: effect on renal haemodynamics and microalbuminuria
Author(s) -
PERSSON B.,
ANDERSSON O. K.,
WYSOCKI M.,
HEDNER T.,
KARLBER B.
Publication year - 1992
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1992.tb00531.x
Subject(s) - isradipine , medicine , endocrinology , microalbuminuria , blood pressure , plasma renin activity , excretion , essential hypertension , atrial natriuretic peptide , hemodynamics , renin–angiotensin system , calcium , dihydropyridine
. Sixteen middle‐aged men with primary hypertension were treated with the calcium antagonist isradipine over a 9‐week period in a randomized, placebo‐controlled, double‐blind cross‐over manner. At the end of the intervention period the urinary albumin excretion rate, systemic and renal haemodynamics, haemorheological properties of blood and plasma concentrations of atrial natriuretic peptide. noradrenaline and peripheral renin activity were determined. Treatment with isradipine resulted in a substantial reduction in blood pressure due to a reduction in peripheral resistance. The mean albumin excretion rate was not influenced by the isradipine treatment. In a multivariate analysis, changes in the urinary albumin excretion rate were only related to changes in blood pressure.