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Gallbladder volume and emptying in diabetics: the role of neuropathy and obesity
Author(s) -
PALASCIANO G.,
PORTINCASA P.,
BELFIORE A.,
BALDASSARRE G.,
CIGNARELLI M.,
PATERNOSTRO A.,
ALBANO O.,
GIORGINO R.
Publication year - 1992
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1992.tb00512.x
Subject(s) - medicine , obesity , diabetes mellitus , gastric emptying , entrapment neuropathy , gallbladder disease , gallbladder , gastroenterology , endocrinology , surgery , stomach , carpal tunnel syndrome
Gallbladder (GB) volume was monitored by real‐time sonography in diabetics ( n = 21) and healthy volunteers ( n = 55) after a test meal. Seventeen controls and seven diabetics were obese; six patients had both autonomous and somatic neuropathy, and four had somatic neuropathy. Fasting GB volume was similar in controls and diabetics with and without autonomic neuropathy; it was correlated with body mass index (controls, r = 0.43, P < 0.002; diabetics, r = 0.46, P < 0.04), and was increased in obese subjects. Post‐prandial GB emptying was decreased in diabetics. Those with autonomous neuropathy exhibited larger residual volumes than controls ( P < 0.03). Post‐prandial GB emptying was slower and less complete in (non‐diabetic) obese subjects and deteriorated further in diabetic obese subjects. GB fasting tone was normal, but GB kinetics were impaired in diabetics; obesity and autonomous neuropathy were correlated with GB hypomotility.