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Levels of cardiovascular risk factors in Type 2 diabetes mellitus are dependent on the stage of proteinuria
Author(s) -
TKÁČ I.,
MOLČÁNYIOVÁ A.,
TKÁČOVÁ R.,
TAKÁC M.
Publication year - 1992
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1992.tb00510.x
Subject(s) - medicine , proteinuria , blood pressure , diabetes mellitus , endocrinology , fibrinogen , creatinine , type 2 diabetes mellitus , risk factor , cholesterol , excretion , kidney
Levels of cardiovascular risk factors were determined in 75 patients with Type 2 diabetes mellitus. The patients were divided into three groups according to their urinary protein excretion (UPE): (a) normal proteinuria (≤ 70 mg d −1 ); (b) microproteinuria (70–500 mg d −1 ): and (c) macroproteinuria (> 500 mg d −1 ). A significant stepwise increase in mean systolic blood pressure, LDL‐cholesterol and fibrinogen levels was observed from the first to the third investigated group of patients. Mean apoprotein B levels were significantly increased in the group with macroproteinuria compared to the other two groups. Significant linear correlations were found between UPE and LDL‐cholesterol, total cholesterol, apoprotein B, creatinine, systolic blood pressure and diabetes duration. In summary, it is concluded that the levels of some cardiovascular risk factors increase with the stage of proteinuria in Type 2 diabetes mellitus.