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Evidence for an independent relationship between insulin resistance and fasting plasma HDL‐cholesterol, triglyceride and insulin concentrations
Author(s) -
LAWS A.,
REAVEN G. M.
Publication year - 1992
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1992.tb00494.x
Subject(s) - medicine , endocrinology , insulin resistance , insulin , triglyceride , body mass index , cholesterol , overweight , high density lipoprotein
. Elevated plasma insulin and triglyceride (TG) and decreased high‐density‐lipoprotein (HDL)‐cholesterol concentrations have been shown to be risk factors for coronary heart disease (CHD). It has been suggested that these metabolic abnormalities are all secondary to resistance to insulin‐stimulated glucose uptake. To examine this in more detail, we divided 18 non‐diabetic, moderately overweight, sedentary men aged 25–50 years into three groups on the basis of their steady‐state plasma glucose levels (SSPG): a low group, ( n = 7; SSPG < 8.3 mmol l −1 ), a middle group, ( n = 6; SSPG 8.3–11.1 mmol l −1 ), and a high group ( n = 5; SSPG > 11.1 mmol l −1 ). The high group had significantly higher fasting ( P < 0.05) and post‐oral glucose challenge ( P < 0.01) insulin concentrations, higher fasting TG ( P < 0.05) and lower fasting HDL‐cholesterol ( P < 0.05) concentrations than the other two groups. However, there were no statistically significant differences between the groups with regard to body mass index, waist‐to‐hip ratio or physical endurance capacity as determined by maximal oxygen consumption during a treadmill test. The data suggest that insulin resistance has an effect on the modulation of plasma insulin, TG and HDL‐cholesterol concentrations, independent of generalized, abdominal or physical endurance capacity.