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Angiotensin‐converting enzyme inhibition and physical training in heart failure
Author(s) -
MEYER T. E.,
CASADEI B.,
COATS A. J. S.,
DAVEY P. P.,
ADAMOPOULOS S.,
RADAELLI A.,
CONWAY J.
Publication year - 1991
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1991.tb00465.x
Subject(s) - lisinopril , medicine , placebo , cardiorespiratory fitness , heart failure , ejection fraction , vo2 max , cardiology , angiotensin converting enzyme , physical exercise , ace inhibitor , heart rate , physical therapy , blood pressure , alternative medicine , pathology
. A total of 12 patients (mean age ± SEM 63 ± 2.6 years) with moderate to severe heart failure (ejection fraction = 23 ± 3.2%) were included in a placebo‐controlled crossover trial. Patients were randomly allocated to 4 periods of 6 weeks each: placebo, placebo and physical training, lisinopril 10 mg daily, and lisinopril and physical training. The exercise time increased from 13.6 ± 0.9 min with placebo to 15 ± 1 min with training alone, and to 16.1 ± 0.7 min with lisinopril and training. With lisinopril alone there was a nonsignificant increase in exercise time, to 14.5 ± 0.6 min. Improvements in exercise time were accompanied by a similar increase in peak oxygen consumption. Overall, the most significant improvements in symptoms and indices of cardiorespiratory fitness were achieved with a combination of lisinopril and training. Thus physical training is not only a useful adjunct to the existing medical therapy for heart failure, but it may also provide symptomatic benefits in its own right.