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Ionized calcium in blood: studies on patients with pulmonary disease
Author(s) -
VADSTRUP S.,
WANDRUP J.
Publication year - 1991
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1991.tb00437.x
Subject(s) - medicine , calcium metabolism , calcium , respiratory acidosis , respiratory disease , carbon dioxide , pco2 , respiratory system , acidosis , arterial blood , endocrinology , gastroenterology , lung , chemistry , organic chemistry
. A new automatic ionized calcium analyser ICA 2 (Radiometer, Copenhagen, Denmark) was used for studies of ionized calcium (C Ca 2+) in the arterial blood of patients with a compensated respiratory acidosis due to chronic lung disease. The data for 16 patients showed an unexpectedly high level of variation in C Ca 2+ (range, 1.01–1.25 mmol l −1 ) despite the fact that there was only a small degree of variability in pH (range, 7.38–7.51). C Ca 2+ was not correlated with pH as has been observed in acute respiratory disturbances. A highly significant negative correlation was found between C Ca 2+ and base excess (BE) (r = − 0.81, P < 0.0001), and between C Ca 2+ and carbon dioxide tension (p co2 ) (r = 0.71, P < 0.002). These correlations differed from those reported previously in acute respiratory disturbances. C Ca 2+ showed a significant positive correlation with oxygen tension (P O2 ) (r = 0.71. P < 0.002). It is concluded that C Ca 2+ in arterial blood from patients with chronic lung disease is correlated with acid‐base and gas quantities in an entirely different manner to that observed in acute acid‐base disturbances in normal adults.