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Zinc sulphate therapy for Wilson's disease after acute deterioration during treatment with low‐dose D‐penicillamine
Author(s) -
VEEN C.,
HAMER C. J. A.,
LEEUW P. W.
Publication year - 1991
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1991.tb00395.x
Subject(s) - penicillamine , medicine , zinc , wilson's disease , urine , gastroenterology , disease , surgery , metallurgy , materials science
. A 30‐year‐old woman with Wilson's disease was treated with low‐dose D‐penicillamine. After 12 days, treatment was changed to zinc sulphate because of severe neurological deterioration. The patient subsequently improved within a few days. During a follow‐up period of 20 months, the effectiveness of therapy was evaluated by measuring copper and zinc levels in plasma and urine, and by 64 Cu‐loading tests. We conclude that sulphate therapy may be a satisfactory alternative, even when rapid deterioration occurs in the early stages of D‐penicillamine treatment.