Premium
Autonomic nerve antibodies and autonomic nerve function in Type 1 and Type 2 diabetic patients
Author(s) -
SUNDKVTST G.,
LIND P.,
BERGSTRÖM B.,
LILJA B.,
RABINOWE S. L.
Publication year - 1991
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1991.tb00386.x
Subject(s) - medicine , autonomic nerve , type 1 diabetes , endocrinology , vagus nerve , autonomic nervous system , diabetes mellitus , diabetic neuropathy , autonomic neuropathy , heart rate , blood pressure , stimulation , biology , cell culture , genetics , neuroblastoma
. Complement‐fixing adrenal medulla (CF‐ADM), sympathetic ganglion (CF‐SG), and vagal (CF‐V) nerve antibodies were determined in diabetic patients. Among 74 patients with Type 1 diabetes, CF‐ADM was detected in 7 (10%) cases, CF‐SG in 14 (19%) cases, and CF‐V in 8 (11%) cases. Among 38 patients with Type 2 diabetes, CF‐ADM was detected in 5 (13%) cases, CF‐SG in 4 (11%) cases, and CF‐V in 6 (16%) cases. There were associations between autonomic nerve antibodies and autonomic nerve function. CF‐ADM and/or CF‐SG were significantly ( P < 0.002) less prevalent in Type 1 diabetic patients with autonomic neuropathy than in those without [5/44 (11%) vs. 14/30 (47%)] and, in agreement with this, the brake index, a sign of parasympathetic and sympathetic autonomic nerve function, was significantly ( P < 0.005) higher (more normal) in these patients (–0.56 ± 0.13 vs. –1.04 ± 0.12). In Type 2 diabetic patients, the E/I ratio, an index of parasympathetic nerve function, was significantly ( P < 0.03) lower (more abnormal) in those with CF‐V than in those without (–1.81 ± 0.17 vs. –1.20 ± 0.11). In conclusion, the frequency of sympathetic nerve antibodies was decreased in Type 1 diabetic patients with autonomic neuropathy, while in Type 2 diabetic patients parasympathetic nerve antibodies were related to severe parasympathetic neuropathy.