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Thrombocytosis in adults: analysis of 777 patients
Author(s) -
SANTHOSHKUMAR C. R.,
YOHANNAN M. D.,
HIGGY K. E.,
ALMASHHADANI S. A.
Publication year - 1991
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1991.tb00383.x
Subject(s) - thrombocytosis , medicine , etiology , malignancy , platelet , myeloproliferative disorders , gastroenterology , pathology
. A total of 777 patients with thrombocytosis, defined as a platelet count of > 500 × 10 9 l −1 , seen in a University hospital over a 1‐year period, were studied prospectively for aetiology. The most frequent causes of thrombocytosis were infection (21.9%), rebound thrombocytosis (19.4%), tissue damage (17.9%), chronic inflammatory disorders (13.1%) and malignancy (5.9%). Thrombocytosis associated with multiple causative factors, occurring simultaneously, was seen in 6.1 % of cases. Thrombocytosis of ≥ 1 million × 10 9 l −1 was found most frequently in patients with multiple aetiological factors occurring at the same time, in myeloproliferative disorders, or in postsplenectomy patients.