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Two IgM paraproteins bearing cryoglobulin and anti‐smooth muscle activities in a patient with Waldenström's macroglobulinaemia
Author(s) -
RUIZPALOMO F.,
REVILLA Y.,
PORQUE P. GONZALEZ,
RIOS M. SERRANO
Publication year - 1991
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1991.tb00312.x
Subject(s) - paraproteins , cryoglobulin , medicine , cryoglobulins , lymphoplasmacytic lymphoma , waldenstrom macroglobulinemia , immunofixation , paraproteinemias , immunology , cryoglobulinemia , pathology , antibody , lymphoma , monoclonal , monoclonal antibody , hepatitis c virus , virus
. A 52‐year‐old white male subject with typical clinical and laboratory findings of Waldenström's macroglobulinaemia is described. Two paraprotein peaks of IgM lambda class, with different physical and chemical properties and different amino acid compositions, in both heavy and light chains, were found in the patient's serum. One of the IgM components (M1) was a cryoglobulin, and the other (M2) showed strong anti‐smooth muscle activity. As far as we know, this is the first report of double paraproteins each of which has different properties.