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Assessment of hypothalamic‐pituitary function in patients with familial amyloidotic polyneuropathy
Author(s) -
OLOFSSON B.O.,
GRANKVIST K.,
OLSSON T.,
BOMAN K.,
FORSBERG K.,
LAFVAS I.,
LITHNER F.
Publication year - 1991
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1991.tb00306.x
Subject(s) - medicine , endocrinology , prolactin , polyneuropathy , hormone , vasopressin
. This study was performed to evaluate hypothalamic‐pituitary hormone regulation in patients with familial amyloidotic polyneuropathy. Twenty‐two patients without clinically overt endocrinological dysfunction were studied. A thyrotropin‐releasing hormone test revealed abnormal growth hormone regulation in 9 of 17 (53%) patients, and abnormal prolactin regulation in 9 of 18 (50%) patients. Abnormalities in either growth hormone or prolactin regulation were found in 12 of 17 (71%) patients. Serum somatomedin C levels were normal in all 22 patients. In 3 of 18 (17%) patients the plasma arginine vasopressin levels were low relative to the serum osmolality levels. Thus abnormalities in hypothalamic‐pituitary hormone regulation may be common in familial amyloidotic polyneuropathy.