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Leakage of HCO 3 − and mucosal restitution
Author(s) -
SILEN W.
Publication year - 1990
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1990.tb01473.x
Subject(s) - nutrient , medicine , intracellular , biophysics , microbiology and biotechnology , chemistry , biology , organic chemistry
. When the integrity of the gastric mucosa is destroyed, there is a large passive diffusion of interstitial HCO 3 − from the nutrient side to the luminal side of the tissue. In the absence of nutrient HCO 3 − , rapid repair of superficial mucosal injuries is slowed markedly down or does not take place at all. The effects of a high degree of luminal acidification, which prevents rapid repair, can be counteracted by high concentrations of nutrient HCO 3 − . The importance of nutrient HCO 3 − is emphasized by the finding that luminal acid may destroy both the fibrin network beneath which restitution occurs and the basal lamina along which viable cells must migrate to re‐establish epithelial continuity. At the present time, it is not known whether the preventive effects of HCO 3 − against ulceration in a variety of systems are dependent upon leakage of HCO 3 − toward the surface, or whether nutrient HCO 3 actually enters cells in order to regulate intracellular pH.