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Influence of dietary cod liver oil on fatty acid composition of plasma lipids in human male subjects after myocardial infarction
Author(s) -
SKÚLADÓTTIR G. V.,
GUDMUNDSDÓTTIR E.,
ÓLAFSDÓTTIR E.,
GUDMUNDSSON T. V.,
HARDARSON T.,
KRISTINSSON Á.,
ÁSVALDSDÓTTIR H.,
SNORRASON S. P.,
GUDBJARNASON S.
Publication year - 1990
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1990.tb00280.x
Subject(s) - docosahexaenoic acid , eicosapentaenoic acid , arachidonic acid , cod liver oil , medicine , fish oil , linoleic acid , cholesterol , crossover study , endocrinology , blood lipids , polyunsaturated fatty acid , fatty acid , biochemistry , chemistry , biology , enzyme , alternative medicine , pathology , fishery , fish <actinopterygii> , placebo
. A randomized crossover study was carried out to investigate the fatty acid profile and concentrations of plasma lipids in male patients with myocardial infarction (MI) who supplemented their diet with 20 ml cod liver oil daily for 6 weeks. Subjects were divided into two groups, A and B. Group A received cod liver oil daily for 6 weeks after hospital discharge, but none for the subsequent 6 weeks. Group B did not start taking cod liver oil until 6 weeks after hospital discharge, and they then took cod liver oil for 6 weeks. Diet, medication or smoking habits were kept as constant as possible during the study. During the period of cod liver oil intake, eicosapentaenoic acid (20:5 (n‐3), EPA) and docosahexaenoic acid (22:6 (n‐3), DHA) increased significantly in phospholipids (PL), triglycerides (TG) and cholesterol esters (CE), whereas linoleic acid (18:2 (n‐6), LA), dihomo‐gamma‐linolenic acid (20:3 (n‐6), DHGLA) and arachidonic acid (20:4 (n‐6), AA) were significantly decreased in phospholipids. The plasma level of TG was significantly decreased during the cod liver oil intake. Total cholesterol, high density lipoprotein (HDL) cholesterol, and levels of apolipoproteins A1 and B were not affected by cod liver oil in these MI patients.