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Coronary artery disease in Chinese males without hypercholesterolaemia
Author(s) -
SHIEH S.M.,
FUH M. M.T.,
SHEN D.C.,
CHEN Y.D. I.,
REAVEN G. M.
Publication year - 1990
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1990.tb00265.x
Subject(s) - medicine , coronary artery disease , cardiology , disease , arterial disease , vascular disease
. The aim of this study was to determine the frequency of various metabolic risk factors for coronary artery disease (CAD) in 246 male patients studied over a 2‐year period. CAD was diagnosed on the basis of a history indicative of angina pectoris, an electrocardiogram diagnostic of myocardial ischaemia, and a positive coronary angiogram. Thirty‐eight per cent of this population had diabetes, hypertension or both. Of the remaining individuals, 39% had a plasma cholesterol concentration ≥ 5.2 mmol l −1 , whereas 23% had a cholesterol concentration < 5.2 mmol l −1 . Plasma lipid and lipoprotein levels of a nonsmoking subset of those subjects with a total cholesterol concentration < 5.2 mmol l −1 were compared with values of a matched group of individuals who did not have significant vessel disease as revealed by angiography. The results of these investigations indicated that patients with CAD and a plasma cholesterol concentration < 5.2 mmol l −1 exhibited an increase in plasma triglyceride concentration and a decrease in plasma HDL‐cholesterol concentration. Since these subjects were not diabetic, hypertensive or hypercholesterolaemic, it is suggested that the observed changes in triglyceride and HDL metabolism made a major contribution to the CAD in these individuals.