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Serum lipoproteins, apolipoproteins and very low density lipoprotein subfractions during 6‐month fibrate treatment in primary hypertriglyceridaemia
Author(s) -
PAUCIULLO P.,
MAROTTA G.,
RUBBA P.,
CORTESE C.,
CARUSO M. G.,
GNASSO A.,
FISCHETTI A.,
MOTTI C.,
MANCINI M.
Publication year - 1990
Publication title -
journal of internal medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.625
H-Index - 160
eISSN - 1365-2796
pISSN - 0954-6820
DOI - 10.1111/j.1365-2796.1990.tb00258.x
Subject(s) - very low density lipoprotein , medicine , endocrinology , cholesterol , apolipoprotein b , lipoprotein , fibrate , triglyceride , lipoprotein lipase , gemfibrozil , high density lipoprotein , adipose tissue
. Serum lipoproteins and apolipoproteins were studied in 14 hypertriglyceridaemic (HTG) patients during a 24‐week period of treatment with gemfibrozil, and after a 6‐week washout period. A marked decrease in very low density lipoprotein (VLDL) cholesterol and triglyceride was observed. There was an increase in high density lipoprotein (HDL) cholesterol, particularly the HDL 3 component. A slight increase in low density lipoprotein (LDL) cholesterol was observed after 12 weeks, but this had almost disappeared after 24 weeks. The treatment resulted in an increase in serum apolipoprotein A‐II levels and a reduction in serum apo C‐III and apo E. VLDL subfractionation by density gradient centrifugation in four subfractions of decreasing size (A, B, C and D) showed a predominant reduction of the large subfractions A, B and C, while the decrease in VLDL‐D was less marked. Percentage changes from the baseline level of VLDL‐A and VLDL‐D cholesterol were found to be inversely correlated with percentage changes in HDL and LDL cholesterol, respectively. This might reflect a transfer of cholesterol from VLDL‐A to HDL, and from VLDL‐D to LDL. The above data suggest fibrate‐induced stimulation of lipoprotein lipase, and indicate that the enhanced transfer of cholesterol from VLDL to LDL, induced by fibrates in HTG patients, is less pronounced after a prolonged period of treatment.